{"id":316556,"date":"2026-06-01T11:06:40","date_gmt":"2026-06-01T09:06:40","guid":{"rendered":"https:\/\/greenowl.fr\/blog\/?p=316556"},"modified":"2026-06-01T11:06:40","modified_gmt":"2026-06-01T09:06:40","slug":"h4cbd-hexahydrocannabidiol","status":"publish","type":"post","link":"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/","title":{"rendered":"H4CBD (hexahydrocannabidiol) : d\u00e9finition, effets, risques et l\u00e9galit\u00e9"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_63 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<p class=\"ez-toc-title\">Sommaire<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a1db15fa4387\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #336449;color:#336449\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" 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href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#Quest-ce_que_le_H4CBD\" title=\"Qu&#8217;est-ce que le H4CBD ?\u00a0\">Qu&#8217;est-ce que le H4CBD ?\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#Histoire_et_decouverte_du_H4CBD\" title=\"Histoire et d\u00e9couverte\u00a0du H4CBD\">Histoire et d\u00e9couverte\u00a0du H4CBD<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#1940%E2%80%AF_Premiere_synthese\" title=\"1940\u202f: Premi\u00e8re synth\u00e8se\u00a0\">1940\u202f: Premi\u00e8re synth\u00e8se\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#2006%E2%80%AF_redecouverte_pharmacologique\" title=\"2006\u202f: red\u00e9couverte pharmacologique\u00a0\">2006\u202f: red\u00e9couverte pharmacologique\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#2021-2022%E2%80%AF_apparition_sur_le_marche_grand_public\" title=\"2021-2022\u202f: apparition sur le march\u00e9 grand public\u00a0\">2021-2022\u202f: apparition sur le march\u00e9 grand public\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#2023-2024%E2%80%AF_reaction_reglementaire\" title=\"2023-2024\u202f: r\u00e9action r\u00e9glementaire\u00a0\">2023-2024\u202f: r\u00e9action r\u00e9glementaire\u00a0<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#Structure_chimique_du_H4CBD\" title=\"Structure chimique\u00a0du H4CBD\u00a0\">Structure chimique\u00a0du H4CBD\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#Quels_sont_les_risques_pour_la_sante%E2%80%AF\" title=\"Quels sont les risques pour la sant\u00e9\u202f?\u00a0\">Quels sont les risques pour la sant\u00e9\u202f?\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#Existe-t-il_un_risque_de_dependance%E2%80%AF\" title=\"Existe-t-il un risque de d\u00e9pendance\u202f?\u00a0\u00a0\">Existe-t-il un risque de d\u00e9pendance\u202f?\u00a0\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#Comparaison_avec_le_CBD_le_HHC_et_le_THC\" title=\"Comparaison avec le CBD, le HHC et le THC\u00a0\">Comparaison avec le CBD, le HHC et le THC\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#Quel_est_son_statut_en_France%E2%80%AF\" title=\"Quel est son statut en France\u202f?\u00a0\u00a0\">Quel est son statut en France\u202f?\u00a0\u00a0<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#La_France_linterdit_depuis_le_3_juin_2024\" title=\"La\u00a0France\u00a0l\u2019interdit depuis le 3 juin 2024\u00a0\">La\u00a0France\u00a0l\u2019interdit depuis le 3 juin 2024\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#LEurope\" title=\"L\u2019Europe\u00a0\u00a0\">L\u2019Europe\u00a0\u00a0<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#Que_dit_lANSM%E2%80%AF\" title=\"Que dit\u00a0l&#8217;ANSM\u202f?\u00a0\">Que dit\u00a0l&#8217;ANSM\u202f?\u00a0<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#Le_H4CBD_fait-il_%E2%80%9Cplaner%E2%80%9D\" title=\"Le H4CBD fait-il &#8220;planer&#8221; ?\u00a0\u00a0\">Le H4CBD fait-il &#8220;planer&#8221; ?\u00a0\u00a0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/greenowl.fr\/blog\/blog-le-cbd\/h4cbd-hexahydrocannabidiol\/#Sources\" title=\"Sources\u00a0\">Sources\u00a0<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2 aria-level=\"2\"><span class=\"ez-toc-section\" id=\"Quest-ce_que_le_H4CBD\"><\/span><span data-contrast=\"none\">Qu&#8217;est-ce que le H4CBD ?<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span data-contrast=\"auto\">Le H4CBD, dont le nom complet est\u00a0hexahydrocannabidiol\u00a0(ou\u00a0t\u00e9trahydrocannabidiol, parfois not\u00e9 H4-CBD, HHCBD ou\u00a0CyclohexylCBD), est un cannabino\u00efde\u00a0h\u00e9misynth\u00e9tique\u00a0d\u00e9riv\u00e9 du CBD.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/greenowl.fr\/histoire-cannabis\/\"><span data-contrast=\"none\">Il ne se trouve pas \u00e0 l&#8217;\u00e9tat naturel dans la plante de cannabis<\/span><\/a><span data-contrast=\"auto\">\u00a0mais\u00a0est\u00a0produit en laboratoire via un proc\u00e9d\u00e9 chimique appel\u00e9 hydrog\u00e9nation, qui consiste \u00e0 ajouter des atomes d&#8217;hydrog\u00e8ne \u00e0 la mol\u00e9cule de CBD.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2 aria-level=\"2\"><span class=\"ez-toc-section\" id=\"Histoire_et_decouverte_du_H4CBD\"><\/span><span data-contrast=\"none\">Histoire et d\u00e9couverte\u00a0du H4CBD<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3 aria-level=\"2\"><span class=\"ez-toc-section\" id=\"1940%E2%80%AF_Premiere_synthese\"><\/span><span data-contrast=\"none\">1940\u202f: Premi\u00e8re synth\u00e8se<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span data-contrast=\"auto\">Le H4CBD a \u00e9t\u00e9 synth\u00e9tis\u00e9 pour la premi\u00e8re fois par Alexander R. Todd en 1940, par hydrog\u00e9nation catalytique du cannabidiol. Todd, futur prix Nobel de chimie en 1957, travaillait \u00e0 \u00e9lucider la structure des cannabino\u00efdes (bien que son Nobel de 1957 ait \u00e9t\u00e9 d\u00e9cern\u00e9 pour ses travaux sur les nucl\u00e9otides et coenzymes). D&#8217;autres d\u00e9riv\u00e9s hydrog\u00e9n\u00e9s du CBD ont \u00e9t\u00e9 produits \u00e0 la m\u00eame p\u00e9riode, notamment le H2CBD (dihydrocannabidiol), ce qui explique une certaine confusion nomenclaturale persistante.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><span class=\"ez-toc-section\" id=\"2006%E2%80%AF_redecouverte_pharmacologique\"><\/span><span data-contrast=\"none\">2006\u202f: red\u00e9couverte pharmacologique<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span data-contrast=\"auto\">En 2006, une \u00e9tude men\u00e9e par Ben-Shabat et al. a \u00e9tabli que les diast\u00e9r\u00e9om\u00e8res du H4CBD se lient au r\u00e9cepteur CB1 avec une forte affinit\u00e9, et que le H4CBD pr\u00e9sente des capacit\u00e9s anti-inflammatoires. C&#8217;est cette publication, sign\u00e9e par une \u00e9quipe incluant Shimon Ben-Shabat, qui constitue aujourd&#8217;hui la r\u00e9f\u00e9rence pharmacologique principale sur le H4CBD [1].<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><span class=\"ez-toc-section\" id=\"2021-2022%E2%80%AF_apparition_sur_le_marche_grand_public\"><\/span><span data-contrast=\"none\">2021-2022\u202f: apparition sur le march\u00e9 grand public<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span data-contrast=\"auto\">Dans le sillage du boom des cannabino\u00efdes alternatifs (HHC en t\u00eate), le H4CBD commence \u00e0 appara\u00eetre sur des plateformes de vente en ligne et dans des boutiques CBD, pr\u00e9sent\u00e9 comme un produit l\u00e9gal aux effets proches d&#8217;un m\u00e9lange CBD\/THC faible dose.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><span class=\"ez-toc-section\" id=\"2023-2024%E2%80%AF_reaction_reglementaire\"><\/span><span data-contrast=\"none\">2023-2024\u202f: r\u00e9action r\u00e9glementaire<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span data-contrast=\"auto\">Face \u00e0 l&#8217;\u00e9mergence de ces substances et aux signalements d&#8217;effets ind\u00e9sirables graves, les autorit\u00e9s sanitaires fran\u00e7aises et europ\u00e9ennes passent \u00e0 l&#8217;action.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2 aria-level=\"2\"><span class=\"ez-toc-section\" id=\"Structure_chimique_du_H4CBD\"><\/span><span data-contrast=\"none\">Structure chimique\u00a0du H4CBD<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span data-contrast=\"auto\">Le CBD (formule C\u2082\u2081H\u2083\u2080O\u2082) est un\u00a0phytocannabino\u00efde\u00a0naturel extrait de la plante\u00a0<\/span><i><span data-contrast=\"auto\">Cannabis sativa<\/span><\/i><span data-contrast=\"auto\">. Sa structure comprend deux cycles aromatiques et, dans sa portion terp\u00e9nique, deux doubles liaisons carbone-carbone (C=C).<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">La synth\u00e8se du H4CBD repose sur l&#8217;hydrog\u00e9nation catalytique : en pr\u00e9sence d&#8217;un catalyseur et d&#8217;un gaz hydrog\u00e8ne sous pression, les deux doubles liaisons du cycle terp\u00e9nique du CBD sont satur\u00e9es par l&#8217;ajout de quatre atomes d&#8217;hydrog\u00e8ne. H4CBD [1,2,8,9-t\u00e9trahydrocannabidiol, nom syst\u00e9matique 2-(2-isopropyl-5-m\u00e9thylcyclohexyl)-5-pentylbenz\u00e8ne-1,3-diol] est pr\u00e9par\u00e9 par r\u00e9duction avec de l&#8217;hydrog\u00e8ne et un catalyseur Pd\/C.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">La formule mol\u00e9culaire obtenue est C\u2082\u2081H\u2083\u2084O\u2082,\u00a0<\/span><a href=\"https:\/\/greenowl.fr\/blog\/blog-cbd-legislation\/hhc-un-point-sur-ce-cannabinoide-de-plus-en-plus-populaire\/\"><span data-contrast=\"none\">elle est\u00a0identique \u00e0 celle du HHC mais avec une structure tridimensionnelle diff\u00e9rente<\/span><\/a><span data-contrast=\"auto\">, ce qui lui conf\u00e8re des propri\u00e9t\u00e9s pharmacologiques distinctes.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2 aria-level=\"2\"><span class=\"ez-toc-section\" id=\"Quels_sont_les_risques_pour_la_sante%E2%80%AF\"><\/span><span data-contrast=\"none\">Quels sont les risques pour la sant\u00e9\u202f?<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span data-contrast=\"auto\">L&#8217;ANSM motiv\u00e9 son interdiction du H4CBD par des signalements r\u00e9els d&#8217;effets graves. Selon\u00a0eux, la consommation de ces substances peut entra\u00eener des effets imm\u00e9diats\u00a0comme\u202f:\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"8\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">des\u00a0vomissements,\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"8\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">une\u00a0perte de connaissance,\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"8\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">un\u00a0coma, des convulsions,\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"8\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"auto\">une\u00a0parano\u00efa, de l&#8217;anxi\u00e9t\u00e9,\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"8\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"5\" data-aria-level=\"1\"><span data-contrast=\"auto\">une\u00a0hypertension art\u00e9rielle,\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"8\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"6\" data-aria-level=\"1\"><span data-contrast=\"auto\">une\u00a0tachycardie.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"auto\">Ces substances miment les effets du THC avec des effets graves et plus intenses que ceux ressentis avec la consommation de cannabis. [7] Depuis le 1er septembre 2023, 90 cas d&#8217;effets ind\u00e9sirables ont \u00e9t\u00e9 signal\u00e9s aux centres d&#8217;\u00e9valuation et d&#8217;information sur la pharmacod\u00e9pendance-addictovigilance (CEIP-A), dont 40 % ont conduit \u00e0 une entr\u00e9e aux urgences ou \u00e0 une hospitalisation. [7]<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2 aria-level=\"2\"><span class=\"ez-toc-section\" id=\"Existe-t-il_un_risque_de_dependance%E2%80%AF\"><\/span><span data-contrast=\"none\">Existe-t-il un risque de d\u00e9pendance\u202f?\u00a0<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span data-contrast=\"auto\">L&#8217;ANSM souligne que ces produits risquent d&#8217;entra\u00eener une d\u00e9pendance. Des consommateurs ont rapport\u00e9 des difficult\u00e9s \u00e0 cesser\u00a0son\u00a0utilisation,\u00a0et sugg\u00e8rent\u00a0un potentiel de d\u00e9pendance psychologique, m\u00eame si celui-ci n&#8217;a pas encore \u00e9t\u00e9 caract\u00e9ris\u00e9 de mani\u00e8re exhaustive dans des \u00e9tudes [7].<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Les mineurs :<\/span><\/b><span data-contrast=\"auto\">\u00a0les produits \u00e0 base de cannabino\u00efdes synth\u00e9tiques sont particuli\u00e8rement dangereux pour les adolescents, dont le syst\u00e8me nerveux est encore en d\u00e9veloppement. Une ingestion accidentelle peut provoquer des effets graves.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Les femmes enceintes ou allaitantes :<\/span><\/b><span data-contrast=\"auto\">\u00a0aucune donn\u00e9e de s\u00e9curit\u00e9 disponible. Toute exposition est \u00e0 proscrire.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Les personnes\u00a0qui souffrent\u00a0de troubles psychiatriques :<\/span><\/b><span data-contrast=\"auto\">\u00a0l&#8217;activit\u00e9 CB1 peut exacerber des troubles anxieux, psychotiques ou d\u00e9pressifs.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"4\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Les conducteurs :<\/span><\/b><span data-contrast=\"auto\">\u00a0la\u00a0psychoactivit\u00e9\u00a0du H4CBD, m\u00eame mod\u00e9r\u00e9e, peut alt\u00e9rer la vigilance et les r\u00e9flexes. La conduite apr\u00e8s consommation est dangereuse et passible de sanctions.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"5\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">L\u2019interaction avec des m\u00e9dicaments\u00a0:<\/span><\/b><span data-contrast=\"auto\">\u00a0comme pour le CBD, des interactions avec des m\u00e9dicaments m\u00e9tabolis\u00e9s par le cytochrome P450 (anticoagulants, anti\u00e9pileptiques, immunosuppresseurs) sont possibles, mais non \u00e9tudi\u00e9es sp\u00e9cifiquement pour le H4CBD.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-ccp-props=\"{}\"> En cas d&#8217;effet ind\u00e9sirable grave, appelez le 15 ou rendez-vous aux urgences. Vous pouvez \u00e9galement d\u00e9clarer le cas sur <a href=\"https:\/\/signalement.social-sante.gouv.fr\/\" target=\"_blank\" rel=\"noopener\">signalement.social-sante.gouv.fr<\/a> ou contacter le CEIP-A de votre r\u00e9gion.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2 aria-level=\"2\"><span class=\"ez-toc-section\" id=\"Comparaison_avec_le_CBD_le_HHC_et_le_THC\"><\/span><span data-contrast=\"none\">Comparaison avec le CBD, le HHC et le THC<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<table data-tablestyle=\"MsoTableGridLight\" data-tablelook=\"1184\" aria-rowcount=\"7\">\n<tbody>\n<tr aria-rowindex=\"1\">\n<td data-celllook=\"0\"><b><span data-contrast=\"auto\">Crit\u00e8re<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><b><span data-contrast=\"auto\">CBD<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><b><span data-contrast=\"auto\">H4CBD<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><b><span data-contrast=\"auto\">HHC<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><b><span data-contrast=\"auto\">THC (\u03949)<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr aria-rowindex=\"2\">\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Origine<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Naturelle (chanvre)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">H\u00e9misynth\u00e9tique<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">H\u00e9misynth\u00e9tique<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Naturelle (cannabis)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr aria-rowindex=\"3\">\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Psychoactivit\u00e9<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Non<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">L\u00e9g\u00e8re \u00e0 mod\u00e9r\u00e9e<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Mod\u00e9r\u00e9e<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Oui (forte)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr aria-rowindex=\"4\">\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Affinit\u00e9 CB1<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-ccp-props=\"{}\">Tr\u00e8s faible (3,3\u20134,8 mM) <\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Mod\u00e9r\u00e9e (145\u00a0nM)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Mod\u00e9r\u00e9e-\u00e9lev\u00e9e<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">\u00c9lev\u00e9e (faible\u00a0nM)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr aria-rowindex=\"5\">\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Statut France (2024)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">L\u00e9gal (sous conditions)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><b><span data-contrast=\"auto\">Stup\u00e9fiant (interdit)<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><b><span data-contrast=\"auto\">Stup\u00e9fiant (interdit)<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Stup\u00e9fiant (interdit)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr aria-rowindex=\"6\">\n<td data-celllook=\"0\"><span data-contrast=\"auto\">\u00c9tudes cliniques humaines<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Oui (nombreuses)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Aucune<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Aucune<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Oui (nombreuses)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<tr aria-rowindex=\"7\">\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Profil de s\u00e9curit\u00e9 \u00e9tabli<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Oui (OMS, ANSM)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Non<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Non<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<td data-celllook=\"0\"><span data-contrast=\"auto\">Oui (partiel)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2 aria-level=\"2\"><span class=\"ez-toc-section\" id=\"Quel_est_son_statut_en_France%E2%80%AF\"><\/span><span data-contrast=\"none\">Quel est son statut en France\u202f?\u00a0<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3 aria-level=\"3\"><span class=\"ez-toc-section\" id=\"La_France_linterdit_depuis_le_3_juin_2024\"><\/span><span data-contrast=\"none\">La\u00a0France\u00a0l\u2019interdit depuis le 3 juin 2024<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span data-contrast=\"auto\">L\u2019ANSM a publi\u00e9 un communiqu\u00e9 intitul\u00e9 &#8220;L&#8217;ANSM inscrit de nouveaux cannabino\u00efdes sur la liste des stup\u00e9fiants&#8221;. Le H4CBD, H2CBD, HHC, HHCP, HHCPO, THCP, THCA sont interdits \u00e0 la production, la vente et l&#8217;usage en France \u00e0 partir du 3 juin 2024. [7]<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Cela signifie que :<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">La production, la vente, l&#8217;achat, la d\u00e9tention et l&#8217;usage\u00a0de H4CBD sont constitutifs d&#8217;une infraction p\u00e9nale en France.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Les sanctions applicables sont celles du droit commun des stup\u00e9fiants (jusqu&#8217;\u00e0 1 an d&#8217;emprisonnement et 3 750 \u20ac d&#8217;amende pour simple usage).<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">Cette interdiction s&#8217;applique \u00e0 toutes les formes de produits : huiles, r\u00e9sines, fleurs, e-liquides,\u00a0gummies, sprays.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<h3 aria-level=\"3\"><span class=\"ez-toc-section\" id=\"LEurope\"><\/span><span data-contrast=\"none\">L\u2019Europe\u00a0<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span data-contrast=\"auto\">Plusieurs \u00c9tats membres de l&#8217;UE ont interdit le HHC d\u00e8s 2023\u00a0comme l\u2019Allemagne,\u00a0l\u2019Autriche,\u00a0la\u00a0Pologne, notamment). La Commission europ\u00e9enne et l&#8217;EMCDDA suivent de pr\u00e8s l&#8217;\u00e9mergence des nouveaux cannabino\u00efdes\u00a0h\u00e9misynth\u00e9tiques.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h2 aria-level=\"2\"><span class=\"ez-toc-section\" id=\"Que_dit_lANSM%E2%80%AF\"><\/span><span data-contrast=\"none\">Que dit\u00a0l&#8217;ANSM\u202f?<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span data-contrast=\"auto\">Le communiqu\u00e9 officiel de l&#8217;ANSM du 24 mai 2024 est la r\u00e9f\u00e9rence r\u00e9glementaire \u00e0 consulter. En voici les \u00e9l\u00e9ments essentiels [7] :<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">\u00c0 cause\u00a0des risques qu&#8217;ils pr\u00e9sentent pour la sant\u00e9 et de leur potentiel d&#8217;abus et de d\u00e9pendance,\u00a0ces cannabino\u00efdes sont inscrits sur la liste des stup\u00e9fiants \u00e0 compter du 3 juin 2024 : les cannabino\u00efdes\u00a0h\u00e9misynth\u00e9tiques, c&#8217;est-\u00e0-dire des substances naturelles modifi\u00e9es chimiquement. Cette famille inclut notamment le HHC, HHCO, HHCP, HHCPO, THCP, THCA, ainsi que le H4CBD et le H2CBD.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">L&#8217;ANSM pr\u00e9cise \u00e9galement que\u00a0<\/span><a href=\"https:\/\/greenowl.fr\/cannabinol-cbn\/\"><span data-contrast=\"none\">le CBN<\/span><b><span data-contrast=\"none\">\u00a0<\/span><\/b><span data-contrast=\"none\">est\u00a0exclu de cette interdiction et reste autoris\u00e9<\/span><\/a><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">En cas d&#8217;effet ind\u00e9sirable li\u00e9 \u00e0 l&#8217;usage de ces substances, l&#8217;ANSM invite \u00e0 d\u00e9clarer les cas sur le portail national de signalement :\u00a0signalement.social-sante.gouv.fr, ou \u00e0 contacter le CEIP-A de sa r\u00e9gion (centre d&#8217;\u00e9valuation et d&#8217;information sur la pharmacod\u00e9pendance-addictovigilance).<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h3 aria-level=\"2\"><span class=\"ez-toc-section\" id=\"Le_H4CBD_fait-il_%E2%80%9Cplaner%E2%80%9D\"><\/span><span data-contrast=\"none\">Le H4CBD fait-il &#8220;planer&#8221; ?\u00a0<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span data-contrast=\"auto\">Il peut provoquer de\u00a0l\u00e9g\u00e8res effets psychoactifs, d\u00e9crit par certains consommateurs comme similaires \u00e0 un m\u00e9lange CBD\/faible dose de THC.\u00a0<\/span><a href=\"https:\/\/greenowl.fr\/cbd-et-thc-quelques-precisions\/\"><span data-contrast=\"none\">Ces effets sont moins intenses que ceux du THC, mais contrairement au CBD pur<\/span><\/a><span data-contrast=\"auto\">, il n&#8217;est pas consid\u00e9r\u00e9 comme non-psychoactif.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<h3 aria-level=\"2\"><span class=\"ez-toc-section\" id=\"Sources\"><\/span><span data-contrast=\"none\">Sources<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><em>[1] Ben-Shabat S, Hanu\u0161 LO, Katzavian G, Gallily R.\u00a0New cannabidiol\u00a0derivatives:\u00a0synthesis, binding to\u00a0cannabinoid\u00a0receptor, and\u00a0evaluation\u00a0of\u00a0their\u00a0antiinflammatory\u00a0activity. Journal of\u00a0Medicinal\u00a0Chemistry.\u00a02006;49(3):1113\u20131117. https:\/\/doi.org\/10.1021\/jm050709m\u00a0<\/em><\/p>\n<p><em>[2] Morales P,\u00a0Reggio\u00a0P,\u00a0Jagerovic\u00a0N.\u00a0An\u00a0overview\u00a0on\u00a0medicinal\u00a0chemistry\u00a0of\u00a0synthetic\u00a0and\u00a0natural\u00a0derivatives\u00a0of cannabidiol.\u00a0Frontiers\u00a0in\u00a0Pharmacology.\u00a02017;8:422. https:\/\/doi.org\/10.3389\/fphar.2017.00422\u00a0<\/em><\/p>\n<p><em>[3] Collins A, Ramirez G,\u00a0Tesfatsion\u00a0T et al.\u00a0Synthesis\u00a0and\u00a0Characterization\u00a0of the\u00a0Diastereomers\u00a0of HHC and H4CBD. Natural Product Communications. 2023. https:\/\/doi.org\/10.1177\/1934578X231158910\u00a0<\/em><\/p>\n<p><em>[4]\u00a0Tesfatsion\u00a0TT, Ramirez GA,\u00a0Docampo-Palacios\u00a0ML et al.\u00a0Evaluation of\u00a0Preclinical\u00a0in vitro\u00a0Cytotoxicity,\u00a0Genotoxicity, and\u00a0Cardiac-Toxicity\u00a0Screenings\u00a0of\u00a0Hydrogenated\u00a0Cannabidiol.\u00a0Pharmacognosy\u00a0Magazine.\u00a02023;19(4):862\u2013873. https:\/\/doi.org\/10.1177\/09731296231195941\u00a0<\/em><\/p>\n<p><em>[5] Ramirez GA et al.\u00a0Saturated\u00a0Cannabinoids:\u00a0Update on\u00a0Synthesis\u00a0Strategies\u00a0and\u00a0Biological\u00a0Studies\u00a0of\u00a0These\u00a0Emerging\u00a0Cannabinoid\u00a0Analogs.\u00a0Molecules.\u00a02023;28(17):6434. https:\/\/doi.org\/10.3390\/molecules28176434 \u2014 NCBI PMC : https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10490552\/\u00a0<\/em><\/p>\n<p><em>[6] Wilson JN, Mendez DA,\u00a0Dhoro\u00a0F et al.\u00a0Pseudocannabinoid\u00a0H4CBD\u00a0improves\u00a0glucose\u00a0response\u00a0during\u00a0advanced\u00a0metabolic\u00a0syndrome in OLETF rats\u00a0independent\u00a0of\u00a0increase\u00a0in\u00a0insulin\u00a0signaling\u00a0proteins. American Journal of\u00a0Physiology\u00a0\u2013\u00a0Regulatory,\u00a0Integrative\u00a0and Comparative\u00a0Physiology.\u00a02024;326(2):R100\u2013R109. https:\/\/doi.org\/10.1152\/ajpregu.00125.2022 \u2014 NCBI PMC : https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11283894\/\u00a0<\/em><\/p>\n<p><em>[7] ANSM \u2013 Agence nationale de s\u00e9curit\u00e9 du m\u00e9dicament et des produits de sant\u00e9.\u00a0L&#8217;ANSM inscrit de nouveaux cannabino\u00efdes sur la liste des stup\u00e9fiants. Communiqu\u00e9 du 24 mai 2024. https:\/\/ansm.sante.fr\/actualites\/lansm-inscrit-de-nouveaux-cannabinoides-sur-la-liste-des-stupefiants\u00a0<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Qu&#8217;est-ce que le H4CBD ?\u00a0 Le H4CBD, dont le nom complet est\u00a0hexahydrocannabidiol\u00a0(ou\u00a0t\u00e9trahydrocannabidiol, parfois not\u00e9 H4-CBD, HHCBD ou\u00a0CyclohexylCBD), est un cannabino\u00efde\u00a0h\u00e9misynth\u00e9tique\u00a0d\u00e9riv\u00e9 du CBD.\u00a0\u00a0 Il ne se trouve pas \u00e0 l&#8217;\u00e9tat naturel dans la plante de cannabis\u00a0mais\u00a0est\u00a0produit en laboratoire via un proc\u00e9d\u00e9 chimique appel\u00e9 hydrog\u00e9nation, qui consiste \u00e0 ajouter des atomes d&#8217;hydrog\u00e8ne \u00e0 la mol\u00e9cule de CBD.\u00a0<\/p>\n","protected":false},"author":2,"featured_media":316558,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[7],"tags":[],"class_list":["post-316556","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog-le-cbd"],"_links":{"self":[{"href":"https:\/\/greenowl.fr\/blog\/wp-json\/wp\/v2\/posts\/316556","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/greenowl.fr\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/greenowl.fr\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/greenowl.fr\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/greenowl.fr\/blog\/wp-json\/wp\/v2\/comments?post=316556"}],"version-history":[{"count":4,"href":"https:\/\/greenowl.fr\/blog\/wp-json\/wp\/v2\/posts\/316556\/revisions"}],"predecessor-version":[{"id":316566,"href":"https:\/\/greenowl.fr\/blog\/wp-json\/wp\/v2\/posts\/316556\/revisions\/316566"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/greenowl.fr\/blog\/wp-json\/wp\/v2\/media\/316558"}],"wp:attachment":[{"href":"https:\/\/greenowl.fr\/blog\/wp-json\/wp\/v2\/media?parent=316556"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/greenowl.fr\/blog\/wp-json\/wp\/v2\/categories?post=316556"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/greenowl.fr\/blog\/wp-json\/wp\/v2\/tags?post=316556"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}